Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (743)
Antibodies (5)

By Effects:	Controls (4) Inhibitors (478) Agonists (10) Antagonists (30) Activators (146) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0772A

Nifekalant hydrochloride	Inhibitor	99.92%
Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC₅₀ of 10 μM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research.

HY-P1427A

Guangxitoxin 1E TFA	Inhibitor
Guangxitoxin 1E TFA is the TFA salt form of Guangxitoxin 1E (HY-P1427). Guangxitoxin 1E TFA is a peptide toxin and a selective inhibitor for voltage-gated potassium channel K_V2.1 and K_V2.2 with IC₅₀ of 1-3 nM. Guangxitoxin 1E TFA enhances glucose-stimulated intracellular calcium ion oscillations and increases insulin secretion in a glucose-dependent manner.

HY-W013712

GI-530159	Activator	99.27%
GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC₅₀ of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect.

HY-100795A

Pirmenol hydrochloride	Inhibitor	99.34%
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation.

HY-N1504

Loureirin B	Inhibitor	99.16%
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10?μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-101253

AM-92016 hydrochloride		≥98.0%
AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse.

HY-124424

VU0071063	Activator	99.71%
VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC₅₀=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships.

HY-117825

RU-TRAAK-2	Inhibitor	99.72%
RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K⁺ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2). RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-18172

KCC2 blocker 1	Inhibitor	98.24%
KCC2 blocker 1 is an orally active and selective K⁺-Cl^- cotransporter KCC2 blocker with an IC₅₀ of 1 μM. KCC2 blocker 1 is a benzyl prolinate.

HY-108583

Psora-4	Inhibitor	99.7%
Psora-4 is a potent and selective inhibitor of K_v1.3 (voltage-gated potassium channels) with an EC₅₀ of 3 nM. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro.

HY-B0480

Brompheniramine maleate	Inhibitor	99.78%
Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.

HY-18600A

Azimilide dihydrochloride	Inhibitor	98.91%
Azimilide (NE-10064) dihydrochloride is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

HY-134320B

8-Azido-ATP trisodium	Inhibitor	99.27%
8-Azido-ATP (8-N3-ATP) trisodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP trisodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP trisodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-112705

VU0529331	Inhibitor	99.81%
VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC₅₀s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel.

HY-102052

DCEBIO	Activator	99.25%
DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl^- secretion in T84 colonic cells. DCEBIO stimulates Cl^- secretion via the activation of hIK1 K⁺ channels and the activation of an apical membrane Cl^- conductance.

HY-B0563S1

Ropivacaine-d₇	Inhibitor	99.38%
Ropivacaine-d₇ is deuterium labeled Ropivacaine. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain management[1].

HY-108594

PD-118057	Activator	≥99.0%
PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability.

HY-19354

Aglafoline	Inhibitor	98.87%
Aglafoline inhibits PAF-induced platelet aggregation, with an IC50 value of 50 μM.

HY-N0663

Talatisamine	Inhibitor	99.75%
Talatisamine, a aconitum alkaloid, is specific K⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons.

HY-108592

UCL 2077	Inhibitor	98.91%
UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC₅₀ = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels.

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (743)

Antibodies (5)

Potassium Channel Related Products (743):